updated March 2006;
Current Interest and work:
The course I teach: Applied System Neuroscience
I graduated from the Medical School of the University of Vienna, Austria, in 1945. I studied Mathematics and Theoretical Physics at the University Vienna from 1946-1948. I completed Psychoanalytic Training with the Psychoanalytic Institute in Pittsburgh in 1975.
My initial research was in Pharmacology. Together with K. Ginzel
and H. Klupp, I developed Succinylcholine as medication for controlled
muscle paralysis in Anesthesiology and Electroshock Therapy. In both
applications, its clinical usefulness has remained unsurpassed for the
past 50 years.
I also undertook the initial neuropharmacological investigation of
Chlorpromazine which became the benchmark and parent compound for a
large class of antipsychotic medications.
After three years, each, on the Faculty of the
School of Tropical Medicine in Calcutta, India, (under the auspices of
WHO), and the University of Sao Paulo, Brazil, I worked with W.F. Riker
at Cornell Medical College, New York City, discovering
pharmacologically active receptors at mammalian motor nerve terminals.
In 1960, I joined Vernon Mountcastle at Johns
Hopkins University: we studied in primates the representation of
tactile and joint sensation in the Somatic Area I of the cerebral
cortex, introducing methods for the quantitative characterization of
single neuron activity. This work launched me in Computer science which
has become a steady involvement ever since. I was a member of the
experimental group that assembled the LINC
computer at MIT, as a new departure for Biomedical Computing.
At present, I am an adj. Professor with the Department of Biomedical Engineering of the University of Texas at Austin.
interests and work are in complex adaptive systems, nonlinear
in the conceptual foundation of Neuroscience. If you are
my current views on these topics, please consult these Web Pages:
in Nervous Systems (2001). The publications
listed below are elaborations and extensions of the viewpoint
outlined in this article.
Siren call of Metaphor: subverting the proper task of Neuroscience: Journal of Integrative Neuroscence 3(3):245-252, 2004.
Perspectives on the Neuroscience of Cognition and Consciousnbess: BioSystems 87:82-95, 2007..
Metastability, Criticality and Phase Transitions in Brain and its Models: BioSystems 90:496-508, 2007.
Brain Dynamics across levels of Organization: Journal of Physiology (Paris): 101: 273-279, 2007.
Consciousness related neural events viewed as Brain State Space Transitions: Cognitive Neurodynamics 3:83-95, 2009.
Viewing brain processes as Critical State Transitions across levels of Organization: Neural events in Cogniiton and Consciousness and general principles: BioSystems 96:114-119, 2009.On critical StateTtransitions between different levels in Neural Systems: New Mathematics and Natural Computation 5(1):185-196, 2009.
Recently, I became
interested in the modulation of neuronal ion channels by the
extracellular environment in which they are
embedded and to which they contribute. To sharpen my intution for possible effects of volume transmission on ion channels
I conducted a simple simulation experiment wich, although quite elementary and requiring much refinement, has suggestive
implications. The conceptual background and the results obtained thus far are reported in the following:
Neural Computation in Excitable Media
For sending E-mail, please click here